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Tuberculosis (TB) is a communicable infectious disease and a major cause of illness, particularly in low-income countries. Thus, the indolizines warrant further development and may represent a novel promising class of InhA inhibitors and multi-targeting agents to combat drug-sensitive and drug-resistant MTB strains. Further, a safety study ( in silico and in vitro) demonstrated no toxicity for these compounds. The X-ray diffraction analysis of the compound 4b was also carried out.
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In silico docking study revealed the enoyl-acyl carrier protein reductase (InhA) and anthranilate phosphoribosyltransferase as potential molecular targets for the indolizines. Compounds 2b–2d, 3a–3d, and 4a–4c were active against the H37Rv-MTB strain with minimum inhibitory concentration (MIC) ranging from 4 to 32 µg/mL, whereas the indolizines 4a–4c, with ethyl ester group at the 4-position of the benzoyl ring also exhibited anti-MDR-MTB activity (MIC = 16–64 µg/mL).
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Customized packaging is also possible when you order in bulk.A series of 1,2,3-trisubstituted indolizines ( 2a–2f, 3a–3d, and 4a–4c) were screened for in vitro whole-cell anti-tubercular activity against the susceptible H37Rv and multidrug-resistant (MDR) Mycobacterium tuberculosis (MTB) strains. If you happen to be a gravity boots seller, you can also enjoy bulk discounts and OEM order placements on request.
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